Usp2 molecular weight

Legend: HelixTurnBeta strandPDB Structure known for this area. USPHydrolase that deubiquitinates polyubiquitinated target proteins such as MDM MDMand CCND1. It is 6amino acids (aa) in length and has a predicted molecular weight of kDa. Human USP2a shares aa sequence identity with the mouse and rat orthologs. USP-and USP-are 3and 3aa in length, respectively, and have predicted molecular weights of and kDa.

Here, we report the structure of the human USPcatalytic domain in complex with. Recombinant Human USPCatalytic Domain is a Ubiquitin-specific. Disclaimer note: The observed molecular weight of the protein may vary from the listed . USPactive domain (human recombinant). C-terminally Histidine-tagged human USPenzyme (active catalytic domain) purified from E. Validated in WB and tested in Human. Immunogen corresponding to recombinant full length protein.

Feb Nelson et al USPCounteracts IDOL-Mediated LDLR Degradation 4route. Complete information for USPgene (Protein Coding), Ubiquitin Specific. Gene Ontology (GO) - Molecular Function for USPGene. USP2b, with molecular weights of ~kDa and ~kDa respectively. In vitro studies revealed that the USPcore was able to deubiquitylate high molecular weight proteins from testis extracts and cleave Ub-PLAwith good . E) Solvent molecules mediating the binding of ubiquitin are shown as blue spheres, and the molecular.

USP, also known as UBPis a deubiquitinating protease which rescues proteins. USPis shown as a gray transparent surface. The catalytic core region of USP(13) was subcloned in pGEX-5X1 . Immunoblotting: Detection of high molecular weight bands with the. Untagged USPcatalytic domain.

SDS-PAGE, following ion exchange . Human USP(Ubiquitin-Specific Protease 2) or UPB4 GenBank Accession No. Formula : mM Tris-HCl, pH 7. As expecte more ubiquitin was present in the high molecular weight region above. Predicted molecular weight : 68 . Molecular Weight : Anti USPdetects a band of approximately kDa in HCT1cell lysates. Product ForPurified IgG - liquid.

USP2b and each protein migrates at its normal molecular weight. This caused a time-dependent removal of the higher molecular weight. More extended incubation with Hfc- Usp-cc resulted in complete removal of the . Both standards contain the same human proteins ranging in molecular mass.

Jul Eight- to twelve-wk-old UspWT and KO mice were fed a normal. Mar Therefore, identification of the core molecular pathway that controls CSC. Animal studies indicate that pharmacological inhibition of USP.

ML3is an inhibitor of ubiquitin specific peptidase ( USP) and can be used for the research of breast cancer. May Relative intensity of high– molecular weight (HMW) AR species is. Oct of generating ROS efficiently, inhibit DUBs such as USPby a novel. USPin the absence or presence of μM NEM, .