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Fast delivery of USPknockout Human Cell Lines for the study of gene function. Includes matched wildtype control. This antibody reacts with Mouse samples.

Apr We performed a targeted siRNA screen for ubiquitin‐specific proteases (USPs) and identified USPas a modulator of TNF‐α‐induced NF‐κB . Jul Dose–response curves for inhibition of USPby Ubvs.

The ICvalue was determined as the concentration of Ubv that reduced USPactivity . Nov Identification of novel inhibitors of USPand USP7. Tested Applications: Immunohistochemistry. Rabbit polyclonal USPantibody. Expression of USP(UBP41) in cancer tissue.

The cancer tissue page shows antibody staining of the protein in different cancers. Untagged USPcatalytic domain. USPHydrolase that deubiquitinates polyubiquitinated target proteins such as MDM MDMand CCND1.

Isoform and isoform possess both . If there are other RefSeq transcripts available they. The Uspgene encodes two isoforms, USP2a and USP2b, kDa and kDa respectively, which share a common core catalytic domain, but have distinct . Oct The human deubiquitinating enzyme ubiquitin-specific protease ( USP) regulates multiple cellular pathways, including cell proliferation and . USP, a cysteine protease and a member of the ubiquitin specific protease family , is overexpressed in prostate cancer and stabilizes fatty acid synthase, which . Deubiquitinating proteases reverse protein ubiquitination and rescue their target proteins from destruction by the proteasome. Reaction was incubated at 37°C for . Recombinant human USPprotein, active and expressed in an Sfexpression system.

Ubiquitin-specific protease ( USP) has a regulatory function in cell growth or death and is involved in the pathogenesis of various . Sep Keywords: cancer biology, cell cycle, enzyme inhibitor, cyclin D drug discovery, ubiquitination, USP, ubiquitin-specific protease. Find the right product on antibodies-online. Deubiquitylase Enzyme Assay: The activity of GST- USPwas validated by determining the increase in fluorescence measured as a result of the enzyme . Feb requires USPenzymatic activity and leads to a marked stabilization.

Nelson et al USPCounteracts IDOL-Mediated LDLR Degradation 411. USP, also known as UBPis a deubiquitinating protease which rescues proteins from the ubiquitin mediated 26S proteasomal pathway. Polyclonal Antibody for studying USPin the Protein Stability research area.

USP(ubiquitin specific peptidase 2), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. Chromosome, Chr0 chr7L, chr7S. AKA: USP deubiquitinating enzyme ubiquitin specific protease USP, ubiquitin-specific-processing protease ubiquitin thioesterase ubiquitin . A) ES cells were targeted with a vector that, upon recombination, inserted LoxP sites upstream of exon and . Compare Anti- USPAntibody Products from leading suppliers on Biocompare.

Pflugers Archiv European Journal of Physiology. Availability of voltage-gated calcium channels (Cav) at the plasma membrane is . ML36 a small molecule inhibitor of the deubiquitinase USP(ICvalue of μM), induced an increase in cellular cyclin Ddegradation and caused cell . Possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). USPGenomewide CRISPR KO cell lines product list. Description: Human USP(Ubiquitin-Specific Protease 2) or UPB4 GenBank Accession No. Dec Transient Kinetic Analysis of USP-Catalyzed Deubiquitination Reveals a Conformational Rearrangement in the K48-Linked Diubiquitin . The gene ubiquitin specific peptidase ( USP) has been shown to regulate target.

To look at the circadian endogenous USPexpression, HepGcells were . Jan Methods and : Using a genetic screening approach we identify the ubiquitin-specific protease ( USP) as a post-transcriptional . USP, cause cell death upon ectopic expression.